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KEYTRUDA is a medication that may treat sure cancers by working with your immune system. KEYTRUDA can cause your immune system to attack regular organs and tissues in any space of your physique and may have an effect on the way in which they work. These problems can generally develop into severe or life-threatening and can result in loss of life. You can have multiple of these problems at the identical time. These issues could occur any time during remedy or even after your therapy has ended.

Call or see your well being care provider straight away in case you develop any signs or signs of the following problems or if they get worse. These aren't the entire signs and symptoms of immune system issues that can occur with KEYTRUDA:

Lung issues: cough, shortness of breath, or chest ache.

Intestinal issues: diarrhea (loose stools) or extra frequent bowel movements than typical; stools which might be black, tarry, sticky, or have blood or mucus; or extreme stomach-area (abdomen) pain or tenderness.

Liver problems: yellowing of your pores and skin or the whites of your eyes; severe nausea or vomiting; ache on the suitable side of your stomach area (abdomen); darkish urine (tea coloured); or bleeding or bruising more simply than regular.

Hormone gland issues: headaches that won't go away or unusual complications; eye sensitivity to gentle; eye issues; fast heartbeat; increased sweating; excessive tiredness; weight gain or weight reduction; feeling more hungry or thirsty than usual; urinating more typically than typical; hair loss; feeling chilly; constipation; your voice will get deeper; dizziness or fainting; changes in temper or behavior, reminiscent of decreased intercourse drive, irritability, or forgetfulness.

Kidney issues: lower in the quantity of your urine; blood in your urine; swelling of your ankles; loss of appetite.

Skin problems: rash; itching; pores and skin blistering or peeling; painful sores or ulcers in your mouth or in your nostril, throat, or genital space; fever or flu-like signs; swollen lymph nodes.

Problems can also happen in other organs and tissues. Signs and symptoms of those problems could embrace: chest pain; irregular heartbeat; shortness of breath; swelling of ankles; confusion; sleepiness; reminiscence problems; changes in temper or behavior; stiff neck; stability problems; tingling or numbness of the arms or legs; double imaginative and prescient; blurry imaginative and prescient; sensitivity to light; eye pain; changes in eyesight; persistent or severe muscle pain or weakness; muscle cramps; low crimson blood cells; bruising.

Infusion reactions that can sometimes be severe or life-threatening. Signs and signs of infusion reactions might include chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feeling like passing out, fever, and again pain.

Rejection of a transplanted organ or tissue. Your well being care supplier should inform you what indicators and symptoms you should report and they'll monitor you, depending on the type of organ or tissue transplant that you've got had.

Complications, together with graft-versus-host illness (GVHD), in people who've received a bone marrow (stem cell) transplant that makes use of donor stem cells (allogeneic). These complications may be serious and may result in death. These complications might happen should you underwent transplantation both before or after being handled with KEYTRUDA. Your health care supplier will monitor you for these complications.

Getting medical therapy right away might help keep these issues from turning into more serious. Your health care provider will examine you for these issues during therapy with KEYTRUDA. They could treat you with corticosteroid or hormone substitute medicines. They can also must delay or utterly stop therapy with KEYTRUDA in case you have severe unintended effects.

Before you receive KEYTRUDA, inform your well being care supplier when you have immune system issues similar to Crohn’s disease, ulcerative colitis, or lupus; have had an organ or tissue transplant, including corneal transplant, or have had or plan to have a bone marrow (stem cell) transplant that makes use of donor stem cells (allogeneic); have had radiation therapy in your chest space; have a situation that impacts your nervous system, such as myasthenia gravis or Guillain-Barré syndrome.

In case you are pregnant or plan to turn out to be pregnant, tell your health care supplier. KEYTRUDA can harm your unborn baby. If you are able to develop into pregnant, you will be given a pregnancy take a look at earlier than you start remedy. Use effective beginning management during treatment with KEYTRUDA and for 4 months after your final dose of KEYTRUDA. Tell them immediately if you think you may be pregnant or you change into pregnant throughout therapy with KEYTRUDA.

Tell your health care supplier if you're breastfeeding or plan to breastfeed. It is not recognized if KEYTRUDA passes into your breast milk. Do not breastfeed throughout treatment with KEYTRUDA and for four months after your last dose of KEYTRUDA.

Tell your well being care supplier about all of the medicines you're taking, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Common uncomfortable side effects of KEYTRUDA when used alone embody feeling drained; ache, together with pain in muscles; rash; diarrhea; fever; cough; decreased appetite; itching; shortness of breath; constipation; bones or joints and stomach-area (abdominal) pain; nausea; and low levels of thyroid hormone.

In kids, when KEYTRUDA is used alone, fever, vomiting, headache, stomach area (abdominal) ache, and low ranges of white blood cells and crimson blood cells (anemia) are more frequent than in adults.

Common uncomfortable side effects of KEYTRUDA when given with certain chemotherapy medicines embrace feeling tired or weak; nausea; constipation; diarrhea; decreased appetite; rash; vomiting; cough; trouble respiration; fever; hair loss; inflammation of the nerves that will cause ache, weakness, and paralysis within the arms and legs; swelling of the lining of the mouth, nose, eyes, throat, intestines, or vagina; mouth sores; headache; weight reduction; stomach-space (abdominal) pain; joint and muscle pain; bother sleeping; bleeding, blisters, or rash on the palms of your fingers and soles of your ft; urinary tract infection; and low ranges of thyroid hormone.

Common uncomfortable side effects of KEYTRUDA when given with chemotherapy with radiation therapy medicines embody feeling tired or weak; nausea; constipation; diarrhea; decreased appetite; rash; vomiting; cough; trouble respiratory; fever; hair loss; inflammation of the nerves that will trigger pain, weakness, and paralysis within the arms and legs; swelling of the lining of the mouth, nostril, eyes, throat, intestines, or vagina; mouth sores; headache; weight reduction; stomach-area (abdominal) ache; joint and muscle ache; trouble sleeping; bleeding, blisters, or rash on the palms of your hands and soles of your toes; urinary tract infection; and low ranges of thyroid hormone.

Common unwanted side effects of KEYTRUDA when given with enfortumab vedotin embrace rash; tingling or numbness of the arms or legs; feeling tired; itching; diarrhea; hair loss; weight loss; decreased appetite; dry eye; nausea; constipation; modifications in sense of taste; and urinary tract infection.

Common unintended effects of KEYTRUDA when given with chemotherapy and bevacizumab embody tingling or numbness of the arms or legs; hair loss; low purple blood cell depend; feeling drained or weak; nausea; low white blood cell count; diarrhea; excessive blood pressure; decreased platelet count; constipation; joint aches; vomiting; urinary tract infection; rash; low levels of thyroid hormone; and decreased appetite.

Common negative effects of KEYTRUDA when given with axitinib embrace diarrhea; feeling tired or weak; excessive blood stress; liver issues; low ranges of thyroid hormone; decreased appetite; blisters or rash on the palms of your arms and soles of your toes; nausea; mouth sores or swelling of the lining of the mouth, nostril, eyes, throat, intestines, or vagina; hoarseness; rash; cough; and constipation.

These are usually not all the doable side effects of KEYTRUDA. Talk to your health care supplier for medical recommendation about side effects.

You are encouraged to report damaging negative effects of prescription medication to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please learn the accompanying Medication Guide for KEYTRUDA and focus on it along with your doctor. The physician Prescribing Information additionally is offered.

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