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Figure 5. The mix of recording the stimulus evoked CAP (triangle) with real time recordings of lactate (black line) enable for a fuller picture of the cellular interactions to emerge. At the onset of aglycemia the lactate falls nearly immediately adopted by the CAP. Glucose is taken up by astrocytes and both saved as glycogen or Healthy Flow Blood pills immediately processed glycolytically to lactate. The lactate is then transported to the axons for oxidative metabolism. Removing glucose from the aCSF or inhibiting glycogen metabolism with DAB or isofagomine causes the lactate to rapidly fall to zero adopted by the CAP. The conclusion from this optic nerve information is that astrocytes include glycogen and release glycogen derived lactate into the interstitial house via the MCT1, from where it is taken up into axons via the MCT2 transporter. Along with this lactate launch underneath circumstances of aglycemia, where the latency to CAP failure will be accelerated by blocking lactate uptake or Healthy Flow Blood pills inhibiting glycogen metabolism, lactate can be launched tonically underneath baseline circumstances.

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