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Pulmonary embolism (PE) is the main cause of in-hospital death and the third most frequent cause of cardiovascular dying. The clinical presentation of PE is variable, and choosing the appropriate treatment for individual patients could be difficult. Historically, treatment of PE has involved a alternative of anticoagulation, thrombolysis or surgical procedure; nonetheless, a range of percutaneous interventional technologies have been developed that are beneath investigation in patients with intermediate-excessive-risk or high-risk PE. These interventional technologies include catheter-directed thrombolysis (with or without ultrasound assistance), aspiration thrombectomy and combos of the aforementioned ideas. These interventional remedy options would possibly result in a more rapid enchancment in proper ventricular perform and pulmonary and/or systemic haemodynamics specifically patients.