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Because of these additional roles, medication that inhibit COX-1 may cause unwanted negative effects. COX-2 inhibitors are a kind of NSAID that selectively blocks the COX-2 enzyme and never the COX-1 enzyme. The goal of COX-2 inhibitors is to scale back pain and inflammation with out dropping the protection of COX-1 within the gastrointestinal tract. This produces fewer gastrointestinal uncomfortable side effects. In 2005, the Fee published a Inexperienced Paper - Promoting the Mental Well being of the Inhabitants as a first response to the World Health Organization's Psychological Well being Declaration for Europe. In 2013, a Joint Action Psychological Well being and Well-being was launched with financial help from the EU Health Programme. It's a three-yr initiative that goals to create a framework for action at European degree and builds on the European Pact for Psychological Well being and Well-being.

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