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Pulmonary embolism (PE) is the main trigger of in-hospital death and the third most frequent trigger of cardiovascular demise. The clinical presentation of PE is variable, and selecting the suitable treatment for individual patients may be difficult. Historically, therapy of PE has concerned a selection of anticoagulation, thrombolysis or surgical procedure; nevertheless, a spread of percutaneous interventional applied sciences have been developed that are under investigation in patients with intermediate-high-risk or high-threat PE. These interventional applied sciences embody catheter-directed thrombolysis (with or without ultrasound help), aspiration thrombectomy and combinations of the aforementioned principles. These interventional therapy choices may result in a extra rapid improvement in right ventricular function and pulmonary and/or systemic haemodynamics in particular patients.